Induction Chemotherapy Inevitably Leads to Inferior Outcome in Combined Modality Treatment for Unresectable Stage III Non-small Cell Lung Cancer
نویسندگان
چکیده
منابع مشابه
Combined modality therapy for stage III non-small-cell lung cancer.
With 40,000 to 50,000 patients diagnosed annually, stage III lung cancer represents approximately one third of all non-small-cell lung cancer cases. It is a heterogeneous disease stage encompassing stage IIIa, for which surgery in combination with chemotherapy and/or radiation therapy represents a treatment strategy for select patients, and stage IIIb, for which chemoradiation represents the pr...
متن کاملOptimal treatment of unresectable stage III non-small cell lung cancer.
JB Stage III non–small cell lung cancer (NSCLC) is defined by involved lymph nodes in the mediastinum (Table). Previously, stage III NSCLC represented approx imately 40% of lung cancer patients. With the advent of positron emission tomography (PET) scan ning, however, that percentage has dropped to approximately 30% because PET can find small distant metastases in some patients that are not ide...
متن کاملSurgery as part of combined modality treatment in stage IIIB non-small cell lung cancer.
BACKGROUND The role of surgery after neoadjuvant chemotherapy in patients with stage IIIB non-small cell lung cancer (NSCLC) remains unclear. METHODS A prospective multicenter trial of neoadjuvant chemotherapy followed by surgery or radiotherapy or both was conducted with 41 patients with stage IIIB NSCLC. End points were toxicity, response, downstaging, complete resectability, and survival. ...
متن کاملTreatment of Stage III Non-small Cell Lung Cancer
Treatment of Stage III Non-small Cell Lung Cancer Objectives: Stage III non-small cell lung cancer (NSCLC) describes a heterogeneous population with disease presentation ranging from apparently resectable tumors with occult microscopic nodal metastases to unresectable, bulky nodal disease. This review updates the published clinical trials since the last American College of Chest Physicians guid...
متن کاملConcurrent chemoradiotherapy for unresectable stage III non-small cell lung cancer.
Over the last two decades, several approaches to multimodality therapy have been investigated in patients with advanced unresectable non-small cell lung cancer. These include induction chemotherapy and concurrent chemoradiotherapy. Both approaches have been shown to be superior to radiation therapy alone. However, in several randomized trials, concomitant chemoradiotherapy was shown to be super...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2012
ISSN: 1556-0864
DOI: 10.1097/jto.0b013e318245a042